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The ORIGINAL copper peptide from Dr. Pickart's laboratory delivers powerful clinical results to effectively reduce the appearance of fine lines and wrinkles and help you look younger than your age.* Mature skin care with skin-firming exclusives such as Two Timing Tightener (DMAE Tightening agent) and exfoliators enhance Skin Biology's copper peptide creams.

STEP 1: Select a copper peptide. Dry skin types should use hydrating creams / Oily-to-combination skin types should use oil-free serums.

STEP 2. Select a hydroxy acid exfoliator.

STEP 3. Enhance with a moisturizer or DMAE tightening agent.

Shop Copper Peptide Creams
Reduce the Appearance of Wrinkles
Basic Regimen

Apply a light layer in the morning. Protect & Restore High Retinol Cream (for dry skin), Skin Signals Solution (for oily skin), or use the NEW! GHK-Cu Crepey Skin Escape on crepey skin texture.

Best Crepey Skin Cream


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Skin Signals Solution


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Protect and Restore Cream


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LacSal Serum


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LacSal Cream


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Effectively exfoliate dead skin cells with a light layer of a hydroxy acid cream or serum in the evening.







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Advanced Regimen

Skin Needling Device


3% GHK VIP Luxury Cream

3% GHK VIP Cream

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Substitute your morning copper peptide with 3% GHK VIP Luxury Cream or Super Cop 2X (stronger concentrations) ---OR use our Micro Needling Kit with a mild copper peptide serum.






GHK MSM serum


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OR enhance your results with GHK+MSM Skin Smoothing & Soothing Serum. Proprietary blend of GHK-Cu (proven anti-aging powerhouse) + skin-healthy antioxidants.






7 Percent GHK Product Accelerant


Boost your results by adding 10-15 drops of 7% GHK Product Accelerant to Skin Signals Solution or Protect & Restore Cream. Mix into a half ounce (15ml) container. Click here for additional tips on how to properly calculate the drops you'll need to effectively enhance any peptide cream/serum.

best wrinkle removal cream








Retinol in Squalane Moisturizer


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Two Timing Tightener 2X Extra Strength Serum


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Additional Options:
Enhance with a light layer of our DMAE quick-firming serum or moisturize with a light biological oil (such as Retinol in Squalane).




Skin Biology Microdermabrasion Cloth


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Dr. Pickart's Face and Body Cleanser


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Using Dr. Pickart's Face & Body Cleanser or with Skin Biology's Microdermabrasion Cloth.




*Disclaimer: This statement is not a guarantee of results. Results may vary. Testimonials found on this site are only examples of what some of our clients have reported. We cannot guarantee similar results as every situation is different.


Testimonials from Clients

Copper Peptide Reviews Before After Photos

Iwanted to share with you a before and after pic at the 2 week mark of taking GHK sublingual (and also using the GHK+MSM Skin Smoothing and Soothing Serum on my eyelids only). You can see a huge SHIFT!! Also I will connect with you soon. I have some more data from my experience. But wow! I can see real changes! All my best,


I never write any reviews for any products. This is my first time to write review. I have been using Skinbio's products for 12 years. Now I'm turning 53 years old. Thanks for Skinbio's Super Cop, my skin feels extremely smooth, wrinkle free. I look at least 10 years younger than my age - I would never give this cream up!


Just wanted to let u know I LOVE the new GHK-Cu Smoothing and Soothing Serum. From the first night I used it, I awoke to smoother softer clearer bright skin...nothing (not even your other great products I have tried) has shown such beautiful results so quickly and each consecutive night that I use it my facial skin improves. Its amazing! Just came back to try and order another trial sample and so relieved you are now offering the full size for sale. Thank you!


Recently, I started getting curious about my boyfriend's skincare routine. He is in his 40’s and looks like he’s in his low 30’s. I started sneaking some of his products (which he exclusively uses your line) and I was astounded with the results.

I consider myself a skincare junkie. I research everything to death. I’ve had problem skin my entire life which has made me spend massive amounts of time and money on products. I have placed three orders from you guys in the last week. I’m so excited to try everything. The science behind your products speaks volumes and my skin, in the theory of short term, results have been shocking.

My bare skin has never looked so clear and my makeup just glides over the products like a dream. I’m in my early 30’s and I’m in that in between acne and aging phase and your line represents the exact pieces I’ve been looking for... I’ve never been treated so well by a company. Thank you so much. Skincare is very important to me and you now have a customer for life.


I love the derma roller and wish I would have gotten one much sooner. I've used it once and followed with Skin Signals Solution. I'm using it for general anti-aging. I do have some deep expression lines and loss of firmness that I'd like to improve. I noticed improvement in minor blemishes the following day. The quick results after one use amazed me and I'm eager to use it again but don't want to over do it.

Submitted by PR

I have been using your products for over 20 years and the results are amazing. I am 74 years old and people think I am 15 or 20 years younger than I am. I have no wrinkles! I also have been using Retin A for a long time. Now I use Retin A a couple of nights a week and Lactic Power or Lacsal Cream the other nights. During the day I use copper peptides (3% GHK Serum or Super CP Serum and Two Timing Tightener 2X). One day a week I let my skin rest and use only Retinol in Squalane Oil. I want to thank you for your work and your interest.


OMG ... I love your new Crepey skin product!! I am 57 and have been using it for about 3 weeks. Skin on my forearms looks less crepey! Yay! My problem is that I want to use it everywhere... Always love your products!!


Thank you again for providing such incredible products. I live and work in Beverly Hills (one of the most aesthetically driven places on Earth, LOL) and have been receiving many compliments on my skin. I happily provide them your website and my glowing recommendations. Thanks for keeping so many people radiant and happy.

T, California

I have been using only Skin Biology for 10 years. I am now 58. I have no wrinkles yet some slight loss of tightness. The skin on my body is the same. The GHK-Cu is wonderful. I also use your hair products and not one grey hair at this stage. I am so grateful for your research and your integrity in your product. The care of my skin health is sorted with Skin Biology for the rest of my life.

SC, Australia

This product [GHK-Cu Crepey Skin Escape] works, and it works fast. I am using it on my arms and legs, and have seen about 60% improvement in both feel and appearance just a week. Before using this product, the skin had a map-like quality, will all kinds of fine crinkles. It looked cracked, just as clay soil that has baked in the summer sun looks. I was using all kinds of scrubs and oils, to no avail. I look forward to seeing the results after a month. I am 63.

-Best, G. Your Loyal Customer
*Disclaimer: Similar results are not guaranteed.

Love, love, love copper peptides! I have been using Dr. Pickart's copper peptides for over 3 yrs now. I started with the trial kit and have now found the products that work best for me (Skin Signals, Super CP Serum, 7% GHK-Cu peptide) I am truly in love with copper peptides. I'm 53 yrs young and have been told I look 10 years younger! My skin is smooth, clear, elastic and basically line free with the exception of some minor eye crinkles. I can go without foundation and look like I'm wearing it. I find the copper peptides especially useful when derma rolling. I started low and slow at the beginning... My husband just had a spot removed from his face and I plan on helping him with his blemish by introducing him to copper peptides.

Submitted by L.
*Disclaimer: Similar results are not guaranteed.

After only 4 months using SB products - I got new Driver's license today, think last one was from about 5 years ago, anyway I look younger, much younger and better in this picture than I did in the previous picture. I use skin signals, lacsal and TTT mainly... I have fairly tough skin and have been seeing damage push up but can't believe overall appearance of skin. I take pics in Photo Booth on Mac and will someday post the improvement. Most noticeable is the eyelids to me, I am still amazed that magazines NEVER mention your products when they do yet another stupid article on skin care and aging. So it is still our best kept secret.

Joanna 05/11
*Disclaimer: Similar results are not guaranteed.

Just want to say thank you to Skin Biology for their wonderful products. I started with CP Serum in August and moved on to Skin Signals Serum about 3 months ago and I am seeing significant improvement to my mouth to chin lines, forehead, under eye area and crows feet. No more nerve injection fillers for me! Amazing.

Submitted by N.T.
*Disclaimer: Similar results are not guaranteed.

Yes, I got my Mom started a simple Skin Biology regimen a few months back. She is well into her 70's and is using Protect & Restore Day Cover in the AM and P&R w/High Retinol at night. LacSal Cream a couple of times a week. She knows nothing about the science behind this, but is using them as beauty products upon my suggestion. Within the last month she got carded twice...not for buying alcohol, but for her beloved "Senior Citizen Discount"... Big Grin...I told her it MUST be the Copper-peptides! She agreed and said she wasn't stopping now... If all you have are the beginning signs of wrinkles and sagging skin, copper-peptides will make your skin renewal relatively simple.

Submitted Anonymously
*Disclaimer: Similar results are not guaranteed.

The lines on my forehead are disappearing...I used Super CP Serum, Emu Oil and a 10 % AHA moisturizer for 9 months with only small improvement in forehead lines. My skin tone improved... but the wrinkles didn't leave.

Then I began taking oral supplements of MSM and vitamin C. Over then next six months I began to see significant decrease in the forehead wrinkles. About 2 weeks ago I replaced the AHA with Exfol Cream and suddenly the wrinkles are disappearing. Amazing!

Submitted by S.J.
*Disclaimer: Similar results are not guaranteed.

Yes! I was having success with using OBagi which is Retin A and Hydroquinone and other products with growth factors. I had success but it was SLOW. Over 6 months and some lines had diminished. I was really interested in the lines on my neck, those rings. Well since adding CPs [copper-peptides], AHAs and Abrasion, it really speeded it up! Some are gone and all have faded. I mean I have a new neck! And my chest area. That has transformed! I mean it is SMOOTH now. I am loving this stuff!

Submitted by W.K.
*Disclaimer: Similar results are not guaranteed.

I received your Protect & Restore skin cream. WOW! I can't believe my little wrinkles are disappearing in just two weeks! I hope to see good results on my scalp (hoping not to wait too much). Please keep up the good work on your products.
Just a note to tell you about my results with Protect & Restore®. I've been using an alpha hydroxy cream product in the morning for two years and it seems to be helping my skin, but I have had a lot of irritation. When I received the Protect & Restore® cream, I just used it (as an experiment) on one side of my face at night for two months, especially around my eyes and forehead. Well, after two months, on the side of my face where I used both Protect & Restore® and the alpha hydroxy cream, the results were outstanding. The skin looked much better and I could see fewer wrinkles. Now I use both products -- the alpha hydroxy cream in the morning and Protect & Restore® in the evening.

My husband says I look much better.

KU, Vashon Island, WA
*Disclaimer: Similar results are not guaranteed.

After I had been using P&R#3 for a time, I visited some old friends who thought (mistakenly) that I had stopped working. At dinner, they kept looking at me and commenting on my skin. Finally one old friend said, "Is your skin the way it looks because you don't have to work anymore?" My skin is looking great and my husband agrees. I'm using P&R#3 at night and the P&R Day Cover in the morning.

BP, Virginia
*Disclaimer: Similar results are not guaranteed.

I'm 37 years old and I just got carded for buying beer. The sales clerk seriously asked me if I was 21. How's THAT for using P&R?

*Disclaimer: Similar results are not guaranteed.

For several years I've used Alpha Hydroxy Acids for skin care and to remove fine lines and wrinkles and for clarity. I found it was quite effective; but there were two problems - it was irritating to my skin and still left little lines around my eyes. I still use Alpha Hydroxy Acids but now I put Alpha Hydroxy on first, then cover it with Protect & Restore®. Protect & Restore® is very soothing and stops the irritation and I no longer get skin redness. I've noticed a firming of skin and a smoothing out of fine lines. Protect & Restore® also makes a nice base for makeup.
Thanks a lot,

IF, Bellevue, WA
*Disclaimer: Similar results are not guaranteed.

I love your products. Been using them for a year now. I was just at a large conference and was told by many people how incredible my skin looks. 2 people did not recognize me ( have not seen them for 3 years) they told me I looked 20!!!! :) I am 36. Keep up the great work.
An extremely happy customer for life.

*Disclaimer: Similar results are not guaranteed.

I love everything I have ordered to date. I have used Blue Copper in the past and I like P&R better. I have been using PR #3 and during the day for a year and a half. At night, I use the Tri-Reduction. Thank you for putting out such great creams. I can not tell you how many people have told me they think I am in my 40's. I do not tell them I am actually 57. Keep up the good work. You have a loyal following.

Submitted by B.P.
*Disclaimer: Similar results are not guaranteed.

Your new skin cream is working wonderfully. I've been using Retin-A® for four years (about 4 times per week) plus a 7% alpha hydroxy cream in the morning. My skin looks smoother but I often get redness and irritation and have to stop using the products for a time.

I started using a light coating of Protect & Restore® cream in the evening about 4 months ago along with the other products. The raw redness is gone and my skin now has very nice looking light pink color (without any makeup). A friend that I had not seen in a year said my face looks 10 years younger.
Many thanks,

CH, Bellevue, WA
*Disclaimer: Similar results are not guaranteed.

Thank you for your Super Cop 2X [Extra Strength] - which I am using. It does tingle but I don't mind as I feel it is working! I also use P&R Cream 3 [Protect & Restore with Retinol] in the morning and Exfol Cream at night (interspersed with Super Cop.) I sometimes put Emu Oil on top of the Super Cop 2X...

I am 61 but look 48-ish - even the American customs/security people at the airport last week checked my age. And at hospitals, they check they have the right person(!)...I have been using your products for some several years now and they are my total lifeline. I could never contemplate using anything else.

Submitted by A.M.
*Disclaimer: Similar results are not guaranteed.

I had blemishes on my face and chest and tried everything for 30 years without much luck. I used BioHeal AM and PM on them - putting it on thick - and in about three weeks they started fading and filling in. The outlines of the blemishes just started fading away. Laugh lines and furrows also filled in.

TM, Tennessee
*Disclaimer: Similar results are not guaranteed.


Disclaimer: Testimonials found on this site are examples of what some of our clients have said about us. We cannot guarantee the results in any case. Your results may vary as every situation is different.

best wrinkle removal creamHow to Use Skin Rejuvenating
Copper Peptides to Fade Fine Lines & Deep Wrinkles

Copper peptides and hydroxy acids are useful for the treatment of wrinkles and for general skin care. Many start with Super GHK-Copper Cream, Protect & Restore with High Retinol, or Super CP Serum in the morning and LacSal Cream (10% hydroxy acid) very lightly in the evening. Then spot treat with Super Cop Cream.

Nourishing Emu Oil for Skin deeply penetrates normal-to-dry skin to provide moisture while Balance Zone works well to control oil in combination-to-oily skin types.

Questions? Need Personalized Care? Call us at 1-800-405-1912 (or 01-425-644-0160) or send an email to




If you have very sensitive skin, always start with a mild copper peptide, such as Super GHK-Copper Cream. Gradually work up to more intensive copper peptides such as Skin Signals, Super Cop, or 3% GHK VIP Luxury Cream. Moderate the products if needed as outlined on our page on Tips on How to Use Copper Peptides Properly or call us at 1-800-405-1912.


Combination-to-oily skin types should use our oil-free serum versions and apply a light moisturizer on top if needed. If you have normal-to-dry skin type, use our hydrating creams. For spot-treating specific areas, Super Cop 2X is a powerful product that works well on nasolabial lines, deep wrinkles between the eyebrows, and expression lines. See VIDEO on How to Fade Smile Lines


You can use the hydroxy acid and copper peptides together, but hydroxy acids work best if kept at a low pH, and mixing with other products can raise the pH level. Apply Lacsal Cream, Exfol Cream, or Lactic Power 10 at the opposite end of the day as your copper peptide.


If you do not see enough progress, you can apply more hydroxy acid during the day. But reduce the amount if your skin becomes irritated. Or try using a stronger hydroxy acid (i.e. lactic acid 40% peel once a month). Or research micro needling devices to help improve penetration of copper peptides and heighten anti-aging results.

Typical results take approximately 4-6 weeks of consistent use. Call us first before discontinuing your regimen. We may have ideas on how you can improve your results.

Contact a Skin Biology representative at 1 800 405 1912 for further help.