Would you trust an untrained "physician" or "dentist" to operate, perform a procedure, or even to give you advice? Why not? Because your health is important to you.
In this manner, would you trust just any online company selling supposed GHK or copper peptides with something as important as your skin? Of course not. At best you would be wasting your money, at worst your skin might be damaged.
Rejuvenating copper peptides are small protein fragments that can bind copper 2+ ions. When used in topical cosmetic products they result in very positive for skin rejuvenation. These are GHK (glycyl-l-histidyl-l-lysine) and the mixed second generation copper products which promote skin health.
However, not all copper peptides help the skin. Some snake venoms contain very toxic copper peptides.
My copper peptides have been shown to improve skin beauty and condition, have been heavily tested by leading dermatologists, and the results published in journals.
I have researched copper peptides and their biological actions for over 50 years, am still researching to this very day, and have published many papers and patents of them.
Some copper peptide products on the market have much too little copper to be effective. Copper 2+ is a vibrant blue so you would expect a solution with a high copper content to be quite blue in color such as our 1% GHK-Cu serum, 3% GHK-Cu Serum, or 7% GHK-Cu Accelerant.
Real GHK-Cu (at 1% concentration) should have this appearance:
Unfortunately, consumers have no real way to know what they are truly buying. We simply want to educate our clients and make sure all of you are well informed.
Mixing EGF and copper peptides is a bad idea. Very little EGF can penetrate the skin. I can find no credible evidence that EGF in cosmetics actually improves skin.
If enough EGF penetrated the skin to have an effect, then there are the toxicity problems of EGF. Wound healing studies with EGF were stopped because the EGF built up in the blood stream. Furthermore, EGF causes serious hair loss. The injection of 2 milligrams of EGF into sheep causes all the wool hair to fall out within a week. Stem cells for the skin arise from the hair follicles and the EGF shuts them down.
Science 24 July 1998: Vol. 281. no. 5376, p. 511
"First man tamed fire. Then he invented agriculture. Now, after 5000 years of shearing sheep by hand, he's created Bioclip, which leaves the job to the sheep. Bioclip is based on a common protein called epidermal growth factor (EGF). Discovered 2 decades ago by biochemist Stanley Cohen of Vanderbilt University in Nashville, Tennessee, EGF stimulates the growth of various types of tissues in animals and causes one type of sheep to molt periodically. CSIRO, the Australian research agency, has spent 20 years looking into how to harness EGF in the sheep industry and has now incorporated it into a biological substitute for shears. At shearing time, says Pat Wilson of CSIRO's animal production facility, a sheep gets an injection of Bioclip and is then fitted with a net that catches the fleece as it falls off, a process that takes about a week. Wilson and the company, Bioclip Pty Ltd. in New South Wales, say they will launch the product commercially in October and anticipate a big demand: The country's $3-billion-a-year wool industry produces 70% of the world's clothing wool. Soon barns Down Under may no longer ring with the sounds of spring shearing--instead, there will be 150 million merinos milling around in hairnets."
With all the explosive breakthroughs of copper peptides in recent scientific literature, there has been a complementary growth of copper peptide products on the market. Most of these copper peptides are pale comparisons (often times literally) to the original copper peptides discovered by me.
These new Internet "skin experts" give advice on copper peptides. They claim various relevant degrees and knowledge. But almost always we can find no evidence of awarded degrees from real universities. We also check the scientific literature for publications or patents and can find nothing. For the record I have a BA in Chemistry and Mathematics from the University of Minnesota and a PhD in Biochemistry from the University of California at San Francisco. You can easily find my publications by searching "Pickart copper peptides" on the Internet.
Copper peptide products with too many ingredients tend to work poorly. When I founded Procyte Corporation to develop copper peptide products, I first tested many creams and ointments used clinically on wound. Very few of these worked well with GHK-copper. Most just cancelled out the copper peptide effects.
Many copper complexes are extremely toxic. For five years, I worked with the Chemistry Department at the University of Washington designing and testing toxic copper complexes for use as anti-cancer drugs. This is why one must be very careful mixing GHK with various ingredients. One well known GHK-copper cream contains triethanolamine. If this obtains copper, then it kills the skin repair fibroblasts when present at a very low concentration.
5.1 David K. Johnson, Terrance B. Murphy, Norman J. Rose, William H. Goodwin, Loren Pickart, Cytotoxic chelators and chelates 1. Inhibition of DNA synthesis in cultured rodent and human cells by aroylhydrazones and by a copper(II) complex of salicylaldehyde benzoyl hydrazone, Inorganica Chimica Acta 01/1982; 67:159-165.
5.2 Loren Pickart, Anti-neoplastic analogs of the growth factor glycyl-L-histidyl-L-lysine copper(II), Inorganica Chimica Acta 01/1983; 79(1-6):305-306 Inhibition of the growth of cultured cells and an implanted fibrosarcoma by aroylhydrazone analogs of the Gly-His-Lys-Cu(II) complex.
5.3 Loren Pickart, William H. Goodwin, William Burgua,Terrance B. Murphy, David K. Johnson, Inhibition of the growth of cultured cells and an implanted fibrosarcoma by aroylhydrazone analogs of the Gly-His-Lys-Cu(II) complex. Biochemical Pharmacology 01/1984; 32(24):3868-71.
5.4 W E Antholine, S Lyman, D H Petering, L Pickart,,Formation of adducts between cupric complexes of known antitumor agents and ehrlich ascites cells, Biological and Inorganic Copper Chemistry, Edited by K. D. Karlin, J. Zubieta, 01/1985: chapter Formation of Adducts Between Cupric Complexes of Known Antitumor Agents and Ehrlich Ascites Tumor Cells: pages 125-137; Adenine, Guilderland, NY, 1985.
Do you know what is in your cosmetic products? You could be purchasing cosmetic cigarettes without your knowledge! There are many so-called "scientifically-proven" cosmeceuticals that emphasize use of foreign compounds or "new ingredients" designed to "renew genes", "repair DNA", or employ "new technology that reverses cell aging".
However, similar to the hundreds of foreign agents in cigarettes, these "revolutionary products" containing "new" artificial compounds that your body has no background of being able to assimilate, the danger lies in what these ingredients are actually doing over the long term in your body.